to go mad
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予定が狂って、出発が大幅に遅れた。
The schedule went wrong, and our departure was greatly delayed.
時計が狂っていて正しい時刻を示していなかった。
The clock was off and was not showing the correct time.
歯車が一つでも狂うと全体に影響が出る。
If even one gear goes wrong, the whole system is affected.